Ikoreshwa rya tekinoroji yo gukuramo inshinge

Pyrogène, izwi kandi nka endotoxine, ikorerwa mu rukuta rudasanzwe rwa bagiteri ya Gram-mbi, ni ukuvuga ibice by'imirambo ya bagiteri.Nibintu bya lipopolysaccharide hamwe na misile ya molekile igereranije kuva ku bihumbi byinshi kugeza ku bihumbi magana, bitewe nubwoko bwa bagiteri iyikora.Mubisubizo byamazi, misa yayo igereranije irashobora gutandukana kuva ibihumbi magana kugeza kuri miriyoni
Niba urugero rwa pyrogene ruvanze mu miti hanyuma rugaterwa mu maraso y’umuntu, bizatera umuriro mwinshi ndetse n’urupfu.Kubwibyo, birakenewe cyane kugabanya ibirungo bya pyrogene mumazi yimiti bishoboka, cyane cyane mugihe inshinge (nka infusion nini) ari nini, icyifuzo cya pyrogen gikwiye gukomera.

Depyrogenation yamazi yo gutera inshinge (cyangwa amazi yo gutera inshinge) numuyoboro wibanze mubikorwa byinganda zimiti kugirango byuzuze amabwiriza yo gupima Pharmacopoeia.Kugeza ubu, uburyo bwa depyrogenation bwatangijwe mubyiciro 3 bikurikira:

1. Uburyo bwo gusibanganya butanga amazi ya depyrogene, akoreshwa nkamazi yo gutera inshinge, gukaraba amazi, nibindi, ariko ikiguzi cyacyo ni kinini.
2. Depyrogenation hakoreshejwe uburyo bwa adsorption.Bumwe mu buryo ni uko hejuru ya adsorbent yamamaza ibintu bya pyrogenic kandi bigatuma ibicuruzwa byanyuramo.Inzira ya kabiri ni uko adsorbent yamamaza ibicuruzwa kandi ikemerera pyrogene gusohoka.
3. Uburyo bwo gutandukanya Membrane yo gukuraho pyrogene nkibikorwa bishya kandi tekinolojiya mishya iramamara kandi ikoreshwa mubikorwa bya farumasi.Ihame rya ultrafiltration kugirango ikure pyrogene ni ugukoresha ultrafiltration membrane ntoya kurenza uburemere bwa molekile ya pyrogene kugirango uhagarike pyrogene.Ubu buryo bwemejwe.Kandi ifite ibyiza byo gukomera kwumurimo muke, umusaruro mwinshi nibicuruzwa byiza.